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24 - feb. - 2020
Diagnostic value of bone marrow biopsy in patients with lymphoplasmacytic B lymphoma

The article “Diagnostic value of Bone marrow core biopsy patterns in Lymphoplasmacytic Lymphoma / Waldeström Macroglobulinemia and description of its mutational profiles by targeted NGS” has recently been published in the international Journal of Clinical Pathology (FI 2,346, JCR).


This original manuscript describes the clinical relevance of the evaluation by multiparameter methods (morphology and histopathology, immunohistochemistry, flow cytometry and mutational study) of bone marrow biopsy for the accurate diagnosis of patients with lymphoplasmacytic B lymphoma / Waldestrom Macroglobulinemia and its distinction from the precursor phase of the disease called Monoclonal Gammopathy of IgM Uncertain Meaning.


In a novel way, the latest generation technology of directed sequencing of the exome is applied by Next Generation Sequencing to characterize the mutational profile of this lymphoid neoplasm using clinical samples.


The work has been developed in the IDIVAL Translational Hematopathology Laboratory, in collaboration with the HUMV Pathology and Hematology Department, the Valdecilla Biobank and the Center for Genomic Regulation of Barcelona.


Ref. Diagnostic value of Bone marrow core biopsy patterns in Lymphoplasmacytic Lymphoma/Waldeström Macroglobulinemia and description of its mutational profiles by targeted NGS. J Clin Pathol 2020 Jan 24 [Online ahead of print]. PMID: 31980558 DOI: 10.1136/jclinpath-2019-206282. Autores: Julia Garcia-Reyero, Nerea Martinez Magunacelaya, Sonia Gonzalez de Villambrosia, Angela Gomez Mediavilla, Marcela Urquieta Lam, Andres Insunza Gaminde, Raul Tonda, Sergi Beltran, Marta Gut, Ainara Gonzalez Pereña y Santiago Montes-Moreno.

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