1. Epidemiology of cancer:
Development of methods for estimating confidence intervals of the population attributable fraction (Stat Med) and its asignation when risk factors are not aditive (J Clin Epidemiol). Analysis of competing risks of death using Gompertzian models (Mech Ageing Develop; J Epidemiol Commun Health; Rev Esp Cardiol), Markov chains with conditional independence (Int J Epidemiol) and in lack of independence (J Clin Epidemiol).
Line started in 2009 when entering the MCC-Spain project. There have been recruited 10000 participants between cases (breast, prostate, colorectal, stomach and Chronic lymphocytic leukemia) and controls in the different nodes of the project (Asturias, Cantabria, León, Guipúzcoa, Navarre, Gerona, Barcelona, Valencia, Murcia, Granada, Huelva and Madrid). The Cantabria node is the 4th in number of participants (after Of Madrid, Barcelona and Leon).
Our group has obtained three FIS projects as IP for this project in 2009 (5 Projects coordinated by the Cantabria node), 2012 (4 projects coordinated by The Madrid node) and 2015 (3 projects coordinated by the Cantabria node), In addition to participating with collaborating researchers in projects of 2011 and 2014 Led by CREAL, the National Center for Epidemiology and the ICO-Belvitge.
MCC-Spain began publishing its results in mid-2015 and at the moment Has published 27 articles, of which the node of Cantabria has led 3 on Consumption of drugs and breast cancer (BMC Cancer, PlosOne and Breast Cancer Research and Treatment).
With the 2015 project, a turn in the project is initiated to transform the cases into Cohorts for the study of prognostic factors. To this end, the Coordinating committee of MCC-Spain, including from November 2016 to Javier Llorca as a follow-up coordinator.
2. Epidemiology of rheumatic diseases:
Line initiated in 2000 in collaboration with the group of Dr. González-Gay (then, In the Hospital Xeral Calde de Lugo). We have worked on rheumatoid arthritis, arteritis Of giant cells, Schönlein-Henoch's disease, ankylosing spondylitis, Psoriatic arthropathy among others, giving rise to a large number of articles in first Decile / quartile and to the presentation of 7 doctoral theses. At this point, we continue Fundamentally in two sub-lines: cardiovascular risk in diseases Rheumatic and genetic factors that influence this risk.
3. Clinical Epidemiology:
In these years, the line of clinical epidemiology has focused The transplant, especially the lung, giving rise to 18 articles and 5 theses.
4. Epidemiological method:
Our old line of epidemiological method has been refocused towards the Research of new methods to study gene-gene and gene-environment interaction; This includes regression with lasso and ridge penalty, artificial neural networks, and Bayesian networks. This refocus should begin to produce End of 2017
5. Social inequalities:
Although still in the initial phase, it is intended to transplant to Spain the HOUSE indicator developed by Dr. Juhn at the Mayo Clinic, as an indicator of socioeconomic inequalities, and to use it to measure health inequalities in a health system such as Spanish, with universal access. The project will be carried out in collaboration with Dr. Juhn and members of the HUMV Pediatrics Service.