Analysis of the BAFF cytokine as a biomarker potential

9 de March de 2020

The IDIVAL Transplant and Autoimmunity group, belonging to the Kidney Disease Research Network (REDINREN) funded by the ISCIII with FEDER funds, has published a recent work in its biomarker line of work associated with the clinical evolution of Renal Transplant.

Renal transplantation is the best treatment for patients with advanced chronic kidney disease compared to the rest of renal replacement therapy techniques, both in survival and in quality of life, in addition to the technique of greater cost-improvement. Thanks to the development of immunosuppressive treatments, the injector rejection rate has been reduced, especially the rejection mediated by T lymphocytes. However, antibody-mediated rejection (AbMR), in which B lymphocytes have a prominent role, remains important. , so the search for biomarkers that help their prediction and diagnosis is essential. In the present work, the role of BAFF has been studied prospectively, an appointment involved in the survival, proliferation, differentiation and maturation of B lymphocytes, as well as of various populations of B lymphocytes, as a biomarker potential, observing that patients with AbMR , developed in the first 12 months after transplantation, presents smaller serum levels pre-transplant BAFF, as well as subpopulations of B lymphocytes with a memory cell phenotype. Similar results were observed at 6 and 12 months after transplantation in patients with subclinical AbMR, detected in the protocol biopsy performed at 12 months after transplantation. The statistical analysis confirmed the role of BAFF in the development of clinical AbMR, specifically of the classic variables. Therefore, it has been proposed that serum levels of BAFF, as well as a polarization of B lymphocytes towards a memory cell phenotype, can be used as non-invasive biomarkers useful in predicting the development of AbMR.

This work published in the International Journal of Molecular Sciences has been funded by the REDINRED Network, the Carlos III Health Institute and the Marqués de Valdecilla Research Institute (IDIVAL).

Ref. High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection. Irure-Ventura J, San Segundo D, Rodrigo E, Merino D, Belmar-Vega L, Ruiz San Millán JC, Valero R, Benito A, López-Hoyos M. Int J Mol Sci. 2020 Jan 25;21(3). pii: E779. doi: 10.3390/ijms21030779.